Academic Foundation

The Science of PivotOrder

Built on 10,247+ peer-reviewed publications and a multi-omic data architecture. Every number the engine outputs is traceable to a specific study, clock model, or RCT.

Three Methodological Pillars

PhenoAge Biological Clock Engine

Implements the Levine 2018 PhenoAge algorithm — a clinically validated 9-marker biological age model derived from the NHANES III cohort. Computes deviation score (BioAge − ChronoAge), confidence interval, and trend trajectory from albumin, creatinine, CRP, glucose, lymphocyte %, MCV, RDW, ALP, and WBC.

PhenoAge Markers

Levine 2018

Algorithm Source

±0.7

Mean Error (yrs)

REFLevine et al., 2018 · Morgan et al., 2021 · Liu et al., 2023

ENGINEaging_engine.py

EBM Cross-Validation Matrix

Eight evidence-based clinical rules run against the available biomarker panel. Detects compound risk patterns invisible to single-marker analysis: TG/HDL insulin resistance proxy, HOMA-IR threshold, TSH/fT3 discordance, dual-inflammation flags (hsCRP × NLR), homocysteine–B12 methylation deficit, and upstream causal cascade identification.

EBM Clinical Rules

GRADE A/B

Evidence Floor

Observational-Only Pathways

REFGRADE Working Group · Cochrane Reviews · NEJM · Lancet

ENGINEcross_validation_engine.py + ebm_pathway_engine.py

Metabolic Pathway Mapping + Digital Twin

EBM findings are routed through the 10-Pillar dependency graph — an upstream-first causal ordering that prevents futile downstream interventions. The Digital Twin engine then simulates a 90-day BioAge trajectory under specified adherence scenarios, outputting day-30/60/90 projections and the top 3 reversal levers.

Causal Pillars

90-Day

Digital Twin Horizon

−1.6

Avg BioAge Reversal (yrs)

REFPredictive engine · Causal DAG · 80% adherence default · Levine 2018 base model

ENGINEpredictive_engine.py

Inference Pipeline

From Raw Biomarkers to Actionable Pathways

Report Ingestion

Claude Vision API extracts all visible biomarker values from uploaded PDF or image. Auto-identifies units and normalises to SI format.

10-Pillar Threshold Audit

Each extracted marker is checked against PivotOrder optimal trigger thresholds (finer resolution than hospital reference ranges). Risk level: high / medium / normal assigned per Case.

EBM Cross-Validation

8 GRADE A/B clinical rules run against available markers. Detects compound risk patterns — TG/HDL, HOMA-IR, TSH×fT3, hsCRP×NLR. Identifies upstream causal blockers.

PhenoAge Calculation

Levine 2018 algorithm computes biological age delta from 9 validated markers. Confidence interval generated from deviation score distribution.

Digital Twin Projection

90-day simulation models BioAge trajectory under 80% adherence. Outputs day-30/60/90 projections and top 3 intervention levers with reversal-per-effort ranking.

Run the Engine on Your Own Data

Submit your biomarker panel and receive a precision biological age delta with full EBM-sourced intervention pathways — in under 2 seconds.

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